Osteosarcoma has a bimodal age distribution with peaks at which age ranges?

Osteosarcoma has a bimodal age distribution with peaks at which age ranges?

• A. 5-9 and 30-40
• B. 0-2 and 50-60
• C. 20-30 and 80-90
• D. 11-13 and over 65

Answer: (D)

Osteosarcoma has two distinct waves of occurrence: a phase during adolescence when rapid bone growth occurs, and a second, much smaller peak in older adults often linked to long-standing bone conditions like Paget disease or prior radiation. The adolescence peak centers around puberty, roughly ages 10–14, so the most representative range is around 11–13. The elderly peak is typically over 65, which aligns with the second peak. That combination—11–13 and over 65—best reflects the disease’s bimodal distribution. The other ranges don’t match these two well-established age groups.

Osteosarcoma has two distinct waves of occurrence: a phase during adolescence when rapid bone growth occurs, and a second, much smaller peak in older adults often linked to long-standing bone conditions like Paget disease or prior radiation. The adolescence peak centers around puberty, roughly ages 10–14, so the most representative range is around 11–13. The elderly peak is typically over 65, which aligns with the second peak. That combination—11–13 and over 65—best reflects the disease’s bimodal distribution. The other ranges don’t match these two well-established age groups.