Acute _____ failure is defined by an increased creatinine x3 and a decrease in GFR by >75% or urine output <0.3 mL/kg/h for 24 hours or anuria for 12 hours.

Acute _____ failure is defined by an increased creatinine x3 and a decrease in GFR by >75% or urine output <0.3 mL/kg/h for 24 hours or anuria for 12 hours.

• A. Renal
• B. Hepatic
• C. Cardiac
• D. Pulmonary

Answer: (A)

Acute kidney injury is defined by a rapid loss of kidney function, shown by objective changes in filtration and urine output. The criteria given—creatinine rising to three times baseline, or a drop in GFR by more than 75%, or urine output falling below 0.3 mL/kg/h for 24 hours or no urine for 12 hours—specifically reflect severe, kidney-directed dysfunction. These thresholds signal a substantial decrease in renal function that requires urgent evaluation and management, regardless of symptoms. The other organ failures do not involve these kidney-specific measurements, so they do not define acute renal failure. Modern terminology often uses acute kidney injury, but the same thresholds are the diagnostic anchors here.

Acute kidney injury is defined by a rapid loss of kidney function, shown by objective changes in filtration and urine output. The criteria given—creatinine rising to three times baseline, or a drop in GFR by more than 75%, or urine output falling below 0.3 mL/kg/h for 24 hours or no urine for 12 hours—specifically reflect severe, kidney-directed dysfunction. These thresholds signal a substantial decrease in renal function that requires urgent evaluation and management, regardless of symptoms. The other organ failures do not involve these kidney-specific measurements, so they do not define acute renal failure. Modern terminology often uses acute kidney injury, but the same thresholds are the diagnostic anchors here.